Metoprolol is a adrenergic antagonist (β2-selective blocker), used to treat cardic disorders like- hypertension, angina pectoris, tachycardia, & heart failure etc.
Dose: 50-225 (immediate release orally), 10-200 mg (extended release orally), 5 mg IV every 2 minutes
Route: Oral, Intravenous
Duration of action: N/A
Trade name: Metolar, Setaloc, Lopressor, Toprol-XL (extended-release formulation)
Therapeutic uses:
Metoprolol has following usage :
- Used to treat essential hypertension, angina pectoris, tachycardia, heart failure, & vasovagal syncope
- Used as secondary prevention after myocardial infarction.
- Used as an adjunct in treatment of hyperthyroidism, and for migraine prophylaxis.
- Extended-release formulation of metoprolol is indicated for the management of chronic heart failure.
Side effects: Adverse effects of Metoprolol are as follows:
- Cardiac failure,
- Hypotension,
- Complete atrioventricular block,
- Bradycardia,
- Second degree atrioventricular block,
- First degree atrioventricular block,
Blurred vision, - Chest pain or discomfort,
- Confusion,
- Sweating,
- Unusual tiredness or weakness.
Contraindications:
- Metoprolol generally is contraindicated for the treatment of acute myocardial infarction in patients with heart rates of < 45 beats per minute, heart block greater than first-degree (PR interval ≥ 0.24 second), systolic blood pressure <100 mm Hg, or moderate to severe heart failure.
