Cinnarizine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Cinnarizine is a first generation H1- receptor blocker & used in preventing the allergic reactions, motion sickness & to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.
Dose : 25-50 mg (Oral)
Route : Oral
Plasma half-life : 3-4 hours
Duration of action : N/A
Bioavailability : ?
Chemical formula : C26H28N2
IUPAC name : (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine
Trade name : Stugeron, Vertigon, Stunarone, Arlevert, Diznil-25
Therapeutic uses : Cinnarizine has following usage :
- Useful in treating & preventing the allergic reactions.
- Can be used for prevention of symptoms of Motion sickness. They are usually not effective if symptoms are already present and, thus, should be taken prior to expected travel.
- It has moderate sedation.
Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors. Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are noticed:
- Diminished alertness and concentration,
- Light headedness
- Motor incoordination,
- Fatigue and tendency to fall asleep
- Dryness of mouth
- Alteration of bowel movement
- Urinary hesitancy
- Blurring of vision
- Epigastric distress
- Acute overdose produces central excitation, tremors, hallucinations, muscular incordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.
Drug Interactions : Cinnarizine may interact with following drugs :
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.