Cinnarizine : Uses, Dosage, Side Effects, Interactions, & Contraindications

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Cinnarizine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names

Cinnarizine is a first generation H1- receptor blocker & used in preventing the allergic reactions, motion sickness & to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.
Dose : 25-50 mg (Oral)
Route : Oral
Plasma half-life : 3-4 hours
Duration of action : N/A
Bioavailability : ?
Chemical formula : C₂₆H₂₈N₂
IUPAC name : (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine
Trade name : Stugeron, Vertigon, Stunarone, Arlevert, Diznil-25
Therapeutic uses : Cinnarizine has following usage :

• Useful in treating & preventing the allergic reactions.
• Can be used for prevention of symptoms of Motion sickness. They are usually not effective if symptoms are already present and, thus, should be taken prior to expected travel.
• It has moderate sedation.

Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors. Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are noticed:

1. Sedation
2. Diminished alertness and concentration,
3. Light headedness
4. Motor incoordination,
5. Fatigue and tendency to fall asleep
6. Dryness of mouth
7. Alteration of bowel movement
8. Urinary hesitancy
9. Blurring of vision
10. Epigastric distress
11. Headache
12. Acute overdose produces central excitation, tremors, hallucinations, muscular incordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.

Drug Interactions : Cinnarizine may interact with following drugs :

Precautions

Before using this medication, tell your doctor or pharmacist

• If you are allergic to it; or if you have any other allergies.
• Your medical history.

Contraindications
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.