Drugs

Antifungal Drugs : Classification, Uses, Side Effects, & Contraindications

Antifungal Drugs : Definition, Classification, Example, Mechanism of Action, Uses, Side Effects, Contraindications, & Interactions

Introduction

  • Antifungal drugs are agents used for superficial and deep (systemic) fungal infections.
  • Infectious diseases caused by fungi, often chronic in nature, are called mycoses.
    Mycotic infections may be superficial and involve only the skin (cutaneous mycoses extending into the epidermis), while others may penetrate the skin, causing subcutaneous or systemic infections.

Classification

Based on class

1. Antibiotics

E.g.

Polyenes Heterocyclic benzofuran
AmphotericinB (AMB) Griseofulvin
Nystatin
Natamycin (Pimaricin)
Hamycin

2. Antimetabolite

E.g.

  • Flucytosine (5-FC)

3. Azoles

E.g.

Topical Systemic
Clotrimazole Ketoconazole
Econazole Fluconazole
Miconazole Itraconazole
Oxiconazole Voriconazole

4. Allylamine

E.g.

  • Terbinafine

5. Other topical agents

E.g.

  • Tolnaftate
  • Undecylenic acid
  • Benzoic acid,
  • Quiniodochlor
  • Ciclopirox olamine
  • Butenafine,
  • Sod. thiosulfate

Based on use

A. Drugs for Subcutaneous & Systemic Mycosis

E.g.

  • Amphotericin B
  • Anidulafungin
  • Caspofungin
  • Fluconazole
  • Flucytosine
  • Itraconazole
  • Ketoconazole
  • Micafungin
  • Posaconazole
  • Voriconazole

B. Drugs for Cutaneous Mycosis

E.g.

  • Clotrimazole
  • Ciclopirox
  • Econazole
  • Griseofulvin
  • Miconazole
  • Nystatin
  • Natamycin (Pimaricin)
  • Oxiconazole
  • Sertaconazole
  • Sulconazole
  • Terconazole
  • Tioconazole
  • Tolnaftate
  • Butenafine
  • Butoconazole
  • Naftifine
  • Terbinafine
  • Undecylenic acid
  • Benzoic acid
  • Quiniodochlor
  • Sodium thiosulfate

For detailed query about Uses, Side Effects, Contraindications, Interactions of antifungal drugs, refer to individual drugs.

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