Xylometazoline : Therapeutic uses, Dosage & Side Effects
Xylometazoline is a adrenergic agonist (direct acting), used as Nasal decongestant for eelieving nasal congestion due to the common cold, hay fever, other upper respiratory tract allergies, or sinus infection. It also soothes nasal discomfort caused by dryness. It may also be used to treat other conditions as determined by your doctor.
Dose : 0.05-0.1% solution
Route : Topical
Plasma Half-life : >10 seconds
Duration of action : 12 hours
Bioavailability : ?
Chemical formula : C16H24N2
IUPAC name : 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Trade name : Otrivin, Otrivine, Antazol, Xylomet, Cirovin, Klarigen, Nasolin, Neo-Rinoleina, Novorin, Olynth, Otrinoz, Otriven, Otrix, Rhinoset,Zenfresh, Naphthyzinium, Xymelyn, Sinutab Nasal Spray, Snup akut, Sudafed, Xylo-COMOD, Xylolin, Xylovit, Olynth, Xynosine, Xymelin, Zymelin, Xylostar, Xylorin, Nasobol, Xylo Mepha, Decozal.
Therapeutic uses : Xylometazoline has following usage :
- Used as Nasal decongestant because of vasoconstriction property.
- Used for the relief of redness of the eyes associated with swimming, colds, and contact lenses.
Points of interest :
- Regular use of Xylometazoline for long periods should be avoided because mucosal ciliary function is impaired: atrophic rhinitis and anosmia can occur due to persistent Vasoconstriction.
Directions for use :
- Do not take by mouth. Xylometazolinenasal is for use only in the nose.
- Rinse with water if this medicine gets in your eyes.
Side effects : Adverse effects of Xylometazoline are as follows:
- CNS depression
- Nervousness,
- Headaches,
- Trouble sleeping,
- Local irritation & stinging sensation,
- Rise in BP,
- Sneezing.
Contraindications :
- Xylometazoline should be used cautiously in hypertensives and in those receiving MAO inhibitors.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
