Trospium chloride : Therapeutic uses, Dosage & Side Effects
Trospium chloride is a synthetic anti-muscarinic cholinergic antagonist, used as vesico-selective agent for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Dose : 20-60 mg
Route : Oral
Plasma Half-life : 20 hours
Duration of action : 20-30 hours
Bioavailability : ?
Chemical formula : C25H30ClNO3
IUPAC name : 3‑(2‑Hydroxy-2,2‑diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1’‑pyrrolidin]-1’‑ium chloride
Trade name : Sanctura, Regurin,
Therapeutic uses : Trospium chloride is used as vesico-selective agent to treat overactive bladder.
Point of interest : Trospium is the only antimuscarinic used for overactive bladder that is eliminated primarily by the kidneys.
Side effects : Following side effects may be elicited :
- Dry mouth,
- Constipation,
- Blurred vision,
- Abdominal pain upper,
- Tachycardia.
Contraindications :
- Trospium Chloride tablets are contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma.
- Contraindicated in patients with known hypersensitivity to the drug or its ingredients.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.