Trihex : Therapeutic uses, Dosage & Side Effects
Trihex / Trihexyphenidyl / Benzhexol is a synthetic anti-muscarinic cholinergic antagonist, used as adjunct to treat parkinson’s disease, parkinsonian syndromes, including antipsychoticinduced extrapyramidal symptoms.
Dose : 2-10 mg
Route : Oral
Plasma half-life : 3.3-4.1 hours
Duration of action : 3-4 hours
Bioavailability : well absorbed
Chemical formula : C20H31NO
IUPAC name : (RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
Trade name : Pacitane, Parbenz, Artane, Apo-Trihex, Parkin
Therapeutic uses : Trihexyphenidyl is used as adjunct to treat Parkinson’s disease, Parkinsonian syndromes, including antipsychoticinduced extrapyramidal symptoms.
Side effects : Commonly observed side effects of Benzhexol are as follows :
- Xerostomia (dryness of the mouth),
- Mood alterations,
- Visual problems,
- Interfere with gastrointestinal peristalsis and are contraindicated in patients with glaucoma, prostatic hyperplasia, or pyloric stenosis,
- Urinary retention,
- Constipation,
- Impairment of memory and organic confusional states (more common in the elderly.)
Contraindications :
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
