Thrombolytic Agents (Fibrinolytic Agents) : Definition, Classification, Example, List, Mechanism of Action, Uses, Side Effects, Contraindications & Interactions
- Thrombolytics are drugs used to lyse thrombi/clot to recanalize occluded blood vessels (mainly coronary artery).
- They are curative rather than prophylactic; work by activating the natural fibrinolytic system.
- In general, venous thrombi are lysed more easily than arterial, and recent thrombi respond better: little effect on thrombi > 3 days old.
- Alteplase (tPA)
- Acute myocardial infarction
- Deep vein thrombosis
- Pulmonary embolism
- Peripheral arterial occlusion