Drugs

Thrombolytic Agents (Fibrinolytic Agents) : Classification, Uses, & Side Effects

Thrombolytic Agents (Fibrinolytic Agents) : Definition, Classification, Example, List, Mechanism of Action, Uses, Side Effects, Contraindications & Interactions

Definition

  • Thrombolytics are drugs used to lyse thrombi/clot to recanalize occluded blood vessels (mainly coronary artery).
  • They are curative rather than prophylactic; work by activating the natural fibrinolytic system.
  • In general, venous thrombi are lysed more easily than arterial, and recent thrombi respond better: little effect on thrombi > 3 days old.

Classification

E.g.

  • Alteplase (tPA)
  • Reteplase
  • Streptokinase
  • Tenecteplase
  • Urokinase

Uses

  • Acute myocardial infarction
  • Deep vein thrombosis
  • Pulmonary embolism
  • Peripheral arterial occlusion
  • Stroke
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