Rivastigmine : Therapeutic uses, Dosage & Side Effects
Rivastigmine is a Cholinergic Agonist (Indirect acting/ Anti-cholinesterase agent Reversible), used in treating mild to moderate dementia (eg, impairment of memory or judgment, abstract thinking, changes in personality) in patients with Alzheimer or Parkinson disease.
Dose : 1.5-13.3 mg
Route : Oral, transdermal patch
Plasma Half-life : 1.5 hours
Duration of action : ?
Bioavailability : 60 to 72%
Chemical formula : C14H22N2O2
IUPAC name : (S)-3-[1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate
Trade name : Exelon
Therapeutic uses : Rivastigmine is used to delay the progression of Alzheimer’s disease
Side effects : GI distress is the primary adverse effect, therefore, following side effects are most frequently observed :
- Excessive cholinergic stimulation, with nausea, diarrhea, and vomiting,
- Dyspepsia,
- Abdominal pain,
- Weight loss,
- Anorexia,
- Dizziness,
- Headache,
- Anxiety,
- Drowsiness,
- Tremor,
- Fatigue,
- Weakness,
- Depression,
- Malaise.
Contraindications :
- Rivastigminetartrate capsules are contraindicated in patients with known hypersensitivity to Rivastigmine, other carbamate derivatives or other components of the formulation
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
