Propranolol is a adrenergic antagonist (non-selective β-blocker), used to treat hypertension, angina etc.
Dose: 10-160 mg (Oral), 2-5 mg ( i.v. injected over 10 min.)
Route: Oral, Intravenlous
Duration of action: N/A
Trade name: Inderal, Ciplar, Betabloc, Innopran XL
Propranolol has following usage :
- Used to treat hypertension although it does not reduce blood pressure in people with normal blood pressure.
- Useful in the chronic management of stable angina (angina pectoris) since it decreases the oxygen requirement of heart muscle.
- Used as prophylactic agent for Myocardial infarction.
- Used prophylactically to reduce migraine episodes.
- May be useful in managing the Hyperthyroidism.
- Used for supraventricular arrhythmias/tachycardias, ventricular arrhythmias/tachycardias, premature ventricular contractions, digitalis-induced tachyarrhythmias, pheochromocytoma, & essential tremor.
- Off-label indications including parkinsonian tremors (sustained-release only), akathisia induced by antipsychotic drugs, variceal bleeding in portal hypertension, and generalized anxiety disorder.
Side effects: Adverse effects of Propranolol are as follows:
- CNS effects like- depression, dizziness, lethargy, fatigue, weakness, visual disturbances, hallucinations, short-term memory loss, emotional lability, vivid dreams (including nightmares),and depression.
- Metabolic disturbances like Fasting hypoglycemia, decreased glycogenolysis.
- Sexual impairment.
- Propranolol is contraindicated in patients with COPD or asthma.