Health

Propranolol : Therapeutic uses, Dosage & Side Effects

Propranolol is a adrenergic antagonist (non-selective β-blocker), used to treat hypertension, angina etc.
Dose: 10-160 mg (Oral), 2-5 mg ( i.v. injected over 10 min.)
Route: Oral, Intravenlous
Duration of action: N/A
Trade name: Inderal, Ciplar, Betabloc, Innopran XL
Therapeutic uses:
Propranolol has following usage :

  • Used to treat hypertension although it does not reduce blood pressure in people with normal blood pressure.
  • Useful in the chronic management of stable angina (angina pectoris) since it decreases the oxygen requirement of heart muscle.
  • Used as prophylactic agent for Myocardial infarction.
  • Used prophylactically to reduce migraine episodes.
  • May be useful in managing the Hyperthyroidism.
  • Used for supraventricular arrhythmias/tachycardias, ventricular arrhythmias/tachycardias, premature ventricular contractions, digitalis-induced tachyarrhythmias, pheochromocytoma, & essential tremor.
  • Off-label indications including parkinsonian tremors (sustained-release only), akathisia induced by antipsychotic drugs, variceal bleeding in portal hypertension, and generalized anxiety disorder.

Side effects: Adverse effects of Propranolol are as follows:

  • Bronchoconstriction,
  • CNS effects like- depression, dizziness, lethargy, fatigue, weakness, visual disturbances, hallucinations, short-term memory loss, emotional lability, vivid dreams (including nightmares),and depression.
  • Metabolic disturbances like Fasting hypoglycemia, decreased glycogenolysis.
  • Arrhythmias,
  • Sexual impairment.

Contraindications:

  • Propranolol is contraindicated in patients with COPD or asthma.
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