Procyclidine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Procyclidine is used as adjunct to treat parkinson’s disease, parkinsonian syndromes, including anti-psychotic drug induced extrapyramidal symptoms (EPS). It may also be used for other conditions as determined by your doctor.
Dose : 5-20 mg
Route : Oral, IM, IV
Plasma half-life : ~12 hours
Duration of action : Around 12 hours
Bioavailability : ?
Chemical formula : C19H30ClNO
IUPAC name : 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
Trade name : Kemadrin, Axeps, Parklid, Prodine, Prolid, Proly, PROPARK-5, Sycline
Therapeutic uses : Procyclidine is used as adjunct to treat Parkinson’s disease, Parkinsonian syndromes, including anti-psychotic drug induced extrapyramidal symptoms.
Side effects : Commonly observed side effects are as follows :
- Xerostomia (dryness of the mouth),
- Mood alterations,
- Visual problems,
- Interfere with gastrointestinal peristalsis and are contraindicated in patients with glaucoma, prostatic hyperplasia, or pyloric stenosis,
- Urinary retention,
- Constipation,
- Impairment of memory and organic confusional states (more common in the elderly).
Drug Interactions : Procyclidine may interact with following drugs :
Precautions
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history, especially of personal or family history of glaucoma (angle-closure type), urinary blockage, GIT blockage, severe ulcerative colitis, myasthenia gravis.
Contraindications
- Angle-closure glaucoma.
- Known hypersensitivity to procyclidine or any ingredient in the formulation.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
