Prazosin : Therapeutic uses, Dosage & Side Effects

Prazosin : Therapeutic uses, Dosage & Side Effects

Prazosin is a adrenergic antagonist (α1-selective blocker), used in treating high blood pressure or benign prostatic hyperplasia (BPH). It may also be used for other conditions as determined by your doctor.
Dose : 0.5-5 mg
Route : Oral
Onset of action : 30–90 minutes
Plasma Half-life : 2–3 hours
Duration of action : 6-8 hours
Bioavailability : ~60%
Chemical formula : C19H21N5O4
IUPAC name : [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone
Trade name : Prazopres, Minipress, Vasoflex, Lentopres, Hypovase
Therapeutic uses : Prazosin has following usage :

  • Primarily used as an hypertensive to treat high blood pressure.
  • May be used to treat Raynauds disease and prostatic hypertrophy or benign prostatic hyperplasia (BPH).

Points of interest : The first dose of α1-selective blocker drugs like- prazosin may produce an exaggerated orthostatic hypotensive response (Postural Hypotension) that can result in dizziness & syncope (fainting).This action, termed a “first-dose” effect, may be minimized by adjusting the first dose to one-third or one-fourth of the normal dose and by giving the drug at bedtime.

Warnings :

  • As with all alpha-blockers, PrazosinHCl may cause syncope with sudden loss of consciousness.

Side effects : Adverse effects of Prazosin are as follows:

  • Dizziness,
  • A lack of energy,
  • Weakness,
  • Nasal congestion,
  • Headache,
  • Nausea,
  • Drowsiness,
  • Orthostatic hypotension,
  • Tachycardia,
  • Palpitations,
  • Sexual dysfunction,
  • Floppy iris syndrome

Contraindications :

  • PrazosinHCl capsules are contraindicated in patients with known sensitivity to quinazolines, Prazosin, or any of the inert ingredients.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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