Pheniramine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Pheniramine is a first generation H1- receptor blocker (Anti-histamine), useful in treating the allergic reactions such as hay fever or urticaria.
Dose : 25-50 mg (Oral)
Route : Oral, Intra-muscular(I.M.), Slow I.V., Topical (Nasal or Opthalmic)
Plasma half-life : ?
Duration of action : 2-4 hours
Bioavailability : ?
Chemical formula : C16H20N2
IUPAC name : N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
Trade name : Avil, Aerovil, Alervil
Therapeutic use : Pheniramine has following usage
- Useful in treating & preventing the allergic reactions.
- It have moderate sedative properties and maybe used in the treatment of insomnia (Somnifacient)
Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors.
Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are remarked:
On CNS
- Sedation (most frequently observed adverse reaction),
- Diminished alertness and concentration,
- Fatigue, lassitude, tinnitus, dizziness, tendency to fall asleep,
- Lack of coordination (Motor incoordination), and tremors,
- Light headedness, headache, euphoria, nervousness,
- Blurring of vision, Diplopia
On GIT
- Alteration of bowel movement,
- Epigastric distress,
- Dryness of mouth,
- Urinary hesitancy ( urinary retention or frequency, and dysuria).
Note:- Although the margin of safety of H1-receptor blockers is relatively high, and chronic toxicity is rare, acute poisoning is relatively common, especially in young children.
Drug Interactions : Pheniramine may interact with following drugs :
Precautions
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history.
Contraindications
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.