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Midodrine : Therapeutic uses, Dosage & Side Effects

Midodrine : Therapeutic uses, Dosage & Side Effects

Midodrine is a adrenergic agonist, used as a vasopressor/antihypotensive agent in rreating dizziness that occurs upon sitting up or standing (orthostatic hypotension).
Dose : 2.5-10 mg
Route : Oral
Plasma half-life : N/A
Duration of action : 4-6 hours
Bioavailability : ?
Chemical formula : C12H18N2O4
IUPAC name : (RS)- N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide
Trade name : Proamatine, Amatine, Gutron, Bramox
Therapeutic uses :
Midodrine is used for treatment of patients with autonomic insufficiency and postural hypotension since it induces rises in blood pressure are associated with both arterial and venous smooth muscle contraction.
Note :-  Midodrine is a prodrug; its activity is due to its conversion to an active metabolite, desglymidodrine.
Warning :
Because Midodrine hydrochloride can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care. The indication for use of Midodrine hydrochloride in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured one minute after standing, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of Midodrine hydrochloride, principally improved ability to carry out activities of daily living, have not been verified.
Precautions :
The potential for supine and sitting hypertension should be evaluated before starting therapy.
Side effects : Adverse effects of Metaraminol are as follows:

  • Pruritus,
  • Paresthesia,
  • Dysuria,
  • Supine hypertension,
  • Piloerection,
  • Pain,
  • Abdominal pain,
  • Chills.

Contraindications :

  • MidodrineHCl tablets are contraindicated in patients with severe organic heart disease, acute renal disease, urinary retention, pheochromocytoma or thyrotoxicosis.
  • MidodrineHCl tablets should not be used in patients with persistent and excessive supine hypertension.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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