Drugs

Lymecycline : Therapeutic uses, Dosage & Side Effects

Lymecycline : Therapeutic uses, Dosage & Side Effects

Lymecycline is an tetracycline antibiotic. It is used to treat a range of infections especially moderately severe acne because of better absorption profile.
Dose :
Route : Oral
Onset of action : ?
Plasma Half-life : 10 hours
Duration of action : ?
Bioavailability : 100% (Oral)
Plasma protein binding : ?
Metabolism : ?
Pregnancy risk category : D
Chemical formula : C29H38N4O10
IUPAC name : (2S)-6-[[[(Z)-[(4S,4aS,5aS,6S,12aS) -4-(Dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-4,4a,5,5a-tetrahydrotetracen-2-ylidene]-hydroxymethyl]amino]methylamino]-2-aminohexanoic acid
Trade name : Tetralysal, Damelium, Tetralisal, Damelium, Eficiclina, Limeciclina, Limeclin
Antibacterial spectrum : Lymecycline has been shown to be active against mmany bacteria.
Therapeutic uses : Lymecycline is indicated for treatment of following infections caused by susceptible strains of bacteria :

  • Acne,
  • Infections in the ear, nose, throat and lungs (e.g. bronchitis)
  • Infections of the gut and urinary tract
  • Sexually transmitted diseases caused by chlamydia
  • Chlamydial infections of the eye (trachoma)
  • Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites; and soft tissue (e.g. skin) infections.

Mechanism of action : Tetracyclines enter susceptible organisms via passive diffusion & by an energy-dependent transport protein mechanism unique to the bacterial inner cytoplasmic membrane. Tetracyclines concentrate intracellularly in susceptible organisms. The drugs bind reversibly to the 30S subunit of the bacterial ribosome. This action prevents binding of aminoacyl-t-RNA to the mRNA–ribosome complex, thereby inhibiting bacterial protein synthesis.
Side effects : Lymecycline can cause following side effects :

  • Irritative effects : Epigastric pain, nausea, vomiting, diarrhoea.
  • Sore or painful tongue or mouth
  • Phototoxicity (Distortion of nails occurs occasionally)
  • Antianabolic effect : Reduce protein synthesis and cause an overall catabolic effect. It induces negative nitrogen balance and can increase blood urea.
  • Increased intracranial pressure is noted insome infants.
  • Hypersensitivity reactions (infrequent) : Skin rashes, urticaria, glossitis, pruritus ani and vulvae, even exfoliative dermatitis have been reported. Complete cross sensitization is exhibited by different tetracyclines.
  • Headache with or without disturbances in eyesight.

Drug Interactions : Lymecycline may interact with following drugs :

  • Retinoids
  • Diuretics (e.g. hydrochlorothiazide)
  • Immunosuppressants
  • Blood-thinning drugs
  • Supplements containing calcium, aluminium, magnesium, zinc or iron
  • Antacids
  • Quinapril

Warnings

  • Lymecycline should be used with caution in patients with kidney or liver problems, systemic lupus erythematosus, or myasthenia gravis.

Contraindications 

  • Contraindicated in persons who have shown hypersensitivity to any of the Tetracyclines.
  • Tetracyclines should not be used in pregnant or breast-feeding women or in children less than 8 years of age.
  • It should not be used in those with severe kidney problems, or those with acute porphyria.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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