Lurasidone : Therapeutic uses, Dosage & Side Effects

Lurasidone : Therapeutic uses, Dosage & Side Effects

Lurasidone is a second-generation atypical antipsychotic drug, can be used in treating schizophrenia, depression associated with bipolar disorder. It may also be used for other conditions as determined by your doctor.
Dose : 20-120 mg
Route : Oral
Plasma Half-life : 18 hours
Duration of action : Long
Bioavailability : 9–19% (oral)
Chemical formula : C28H36N4O2S
IUPAC name : (3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl] cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione
Trade name : Latuda
Therapeutic uses :  Lurasidone has following usage :

  • Primarily indicated as anti-psychotic drug for treating psychoses particularly Schizophrenia (generally first-line therapy).
  • Indicated for the treatment of bipolar depression.
  • Can be used as tranquilizers to manage agitated and disruptive behavior secondary to other disorders.

Side effects :  Adverse effects of the Lurasidone can occur in practically all patients and are significant in about 80% ; Lurasidone may produce following side effects:

  • CNS ailments like Sedation, drowsiness, lethargy, mental confusion, increased appetite, weight gain, aggravation of seizures
  • CVS effects including Postural (orthostatic) hypotension, palpitation, inhibition of ejaculation
  • Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary incontinence
  • Nausea, Vomiting,
  • Rarely Hyperprolactinemia – amenorrhoea, infertility, galactorrhoea and gynaecomastia
  • Rarely Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute muscular dystonias, Akathisia, Malignant neuroleptic syndrome, Tardive dyskinesia

Contraindications :

  • It should be used cautiously in patients with seizure disorders (since it may lower the seizure threshold)or those with an increased risk for seizures, such as withdrawal from alcohol.
  • Lurasidone is contraindicated in individuals who are taking strong CYP3A4 inhibitors (ketoconazole, clarithromycin, ritonavir, levodropropizine, etc.) or inducers (carbamazepine, St. John’s wort, phenytoin, rifampicin etc.).
  • The use of lurasidone in pregnant women has not been studied and is not recommended, although it should be noted that it is a category B drug.Excretion in breast milk is also unknown; lurasidone is not recommended for breastfeeding women.
  • In the United States it is not indicated for use in children.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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