Hyoscine : Therapeutic uses, Dosage & Side Effects
Hyoscine / Scopolamine (levo-duboisine / burundangais) a natural anti-muscarinic cholinergic antagonist, used for prevention of motion sickness, postoperative nausea & vomiting and treating certain types of muscle problems (eg, some Parkinson-like conditions, certain muscle spasm problems) & certain stomach or intestinal problems (eg, irritable colon syndrome).
Dose : 0.3-0.5 mg oral
Route : Oral, Intra-muscular(I.M.), Transdermal patch
Plasma half-life : 4.5 hours
Duration of action : >3-4 hours
Bioavailability : ?
Chemical formula : C17H21NO4
IUPAC name : (–)-(S)-3-Hydroxy-2-phenylpropionic acid (1R,2R,4S,7S,9S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester
Trade name : Isopto hyoscine, Transderm scop
Therapeutic uses : Scopolamine is Used for prevention of motion sickness and postoperative nausea and Vomiting.
Points of interest :
- Scopolamine has greater action on the CNS (unlike atropine, CNS effects are observed at therapeutic doses).
- Scopolamine has a Faster onset of action than atropine.
- Scopolamine has a longer duration of action as compared to atropine.
- For motion sickness, it is available as a topical patch that provides effects for up to 3 days.
- As with all drugs used for motion sickness, it is much more effective prophylactically than for treating motion sickness once it occurs.
Side effects : Commonly observed side effects are as follows :
- Dry mouth, blurred vision, xerostomia,tachycardia, hot & flushed skin, urinary retention, and constipation.
- Effects on the CNS include restlessness, confusion, agitation, hallucinations, and delirium, which may progress to depression, collapse of the circulatory and respiratory systems, and death.
- Body temperature is elevated.
Contraindications :
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
