Drugs

Glycopyrrolate : Uses, Dosage, Side Effects, Interactions, & Contraindications

Glycopyrrolate : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names

Glycopyrrolate is a synthetic anti-muscarinic cholinergic antagonist, used for pre-anaesthetic medication and during anaesthesia.
Dose: 1-2 mg oral, 0.1-0.3 mg I.M.
Route: Oral, I.M.
Duration of action: N/A
Trade name: Glyco-P, Pyrolate
Therapeutic uses: Glycopyrrolate is almost exclusively used for pre-anaesthetic medication and during anaesthesia.
Side effects: Commonly observed side effects are as follows :

  • Body aches or pain
  • Chills
  • Constipation
  • Cough
  • Decrease in the frequency of urination & urine volume
  • Difficulty in passing urine (dribbling)
  • Difficulty with breathing
  • Ear congestion
  • Fever
  • Nasal congestion
  • Sore throat
  • Unusual tiredness or weakness

Drug Interactions : Glycopyrrolate may interact with following drugs :

  • Potassium tablets/capsules
  • Pramlintide
  • Azole anti-fungal drugs such as ketoconazole, itraconazole
  • Digoxin (slowly-dissolving forms)
  • Anticholinergic drugs (such as atropine, scopolamine)
  • Antispasmodic drugs (such as clidinium, dicyclomine, propantheline)
  • Belladonna alkaloids
  • Trihexyphenidyl
  • Disopyramide, Quinidine
  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
  • Phenothiazines (chlorpromazine)
  • Tricyclic antidepressants (amitriptyline)

Precautions

Before using this medication, tell your doctor or pharmacist

  • If you are allergic to it; or if you have any other allergies.
  • Your medical history, especially of especially of glaucoma, heart problems, high BP, liver disease, seizures, GIT problems, heartburn problems, hyperthyroidism, urinary problems, kidney problems, autonomic neuropathy, myasthenia gravis.

Contraindications

  • Contraindicated in patients with known hypersensitivity to clonidine or to any other component of the therapeutic system.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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