Edrophonium : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Edrophonium is a Cholinergic Agonist (Indirect acting/ Anti-cholinesterase agent Reversible), used for treatment of myasthenia gravis, post-operative decurarization.
Dose: 1-10 mg (I.V.)
Route: Intra-venous (I.V.)
Plasma half-life: N/A
Duration of action: 10-30 min
Bioavailability: N/A
Chemical formula: C10H16NO+
IUPAC name: N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium
Trade name: Enlon, Tensilon
Therapeutic uses: Edrophonium has following usage :
- Used in the diagnosis of myasthenia gravis.
- Used for post-operative decurarization.
- May also be used to assess cholinesterase inhibitor therapy, for differentiating cholinergic and myasthenic crises, and for reversing the effects of non-depolarizing neuromuscular blockers after surgery.
Note :- Due to the availability of other agents, edrophonium use has become limited.
Side effects: Edrophonium causes following adverse effects :
- Excess drug may provoke a cholinergic crisis (atropine is the antidote).
Drug Interactions : Edrophonium may interact with following drugs :
Precautions
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history, especially of kidney disease, heart rhythm problems.
Contraindications
- Contraindicated in patients with known hypersensitivity to edrophonium.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
