Drugs for Neurodegenerative diseases
Introduction
- Neurodegenerative diseases of the CNS include Parkinson’s disease, Alzheimer’s disease, MS, and ALS.
- These devastating illnesses are characterized by the progressive loss of selected neurons in discrete brain areas, resulting in characteristic disorders of movement, cognition, or both.
Antiparkinson Drugs
A. Drugs affecting brain dopaminergic system
Class | E.g. |
Dopamine precursor | Levodopa |
Peripheral decarboxylase inhibitors | Carbidopa Benserazide |
Dopaminergic agonists | Bromocriptine Ropinirole Pramipexole Rotigotine Apomorphine |
MAO-B inhibitor | Selegiline (Deprenyl) Rasagiline |
COMT inhibitors | Entacapone Tolcapone |
Dopamine facilitator | Amantadine |
B. Drugs affecting brain cholinergic system
Class | E.g. |
Central anticholinergics | Trihexyphenidyl (Benzhexol) Procyclidine Biperiden Benztropine |
Antihistaminics | Orphenadrine Promethazine |
Antialzheimer Drugs
Acetylcholinesterase Inhibitors | NMDA Receptor Antagonist |
Donepezil | Memantine |
Galantamine | |
Rivastagmine |
Antimultiple Sclerosis
Acute Treatment | Disease Modifying Drugs | Symtomatic Treatment |
Methylprednisolone | Interferon β1a & β1b | Dalfampridine |
Natalizumab | ||
Glatiramer | ||
Fingolimod | ||
Teriflunomide | ||
Dimetyl fumarate | ||
Mitoxantrone |
For detailed query about Uses, Side Effects, Contraindications, Interactions of opioid drugs, refer to individual drugs.
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