Drugs

Drugs for Neurodegenerative diseases

Drugs for Neurodegenerative diseases

Introduction

  • Neurodegenerative diseases of the CNS include Parkinson’s disease, Alzheimer’s disease, MS, and ALS.
  • These devastating illnesses are characterized by the progressive loss of selected neurons in discrete brain areas, resulting in characteristic disorders of movement, cognition, or both.

Antiparkinson Drugs

A. Drugs affecting brain dopaminergic system

Class E.g.
Dopamine precursor Levodopa
Peripheral decarboxylase inhibitors Carbidopa
Benserazide
Dopaminergic agonists Bromocriptine
Ropinirole
Pramipexole
Rotigotine
Apomorphine
MAO-B inhibitor Selegiline (Deprenyl)
Rasagiline
COMT inhibitors Entacapone
Tolcapone
Dopamine facilitator Amantadine

B. Drugs affecting brain cholinergic system

Class E.g.
Central anticholinergics Trihexyphenidyl (Benzhexol)
Procyclidine
Biperiden
Benztropine
Antihistaminics Orphenadrine
Promethazine

Antialzheimer Drugs

Acetylcholinesterase Inhibitors NMDA Receptor Antagonist
Donepezil Memantine
Galantamine
Rivastagmine

Antimultiple Sclerosis

Acute Treatment Disease Modifying Drugs Symtomatic Treatment
Methylprednisolone Interferon β1a  &  β1b Dalfampridine
Natalizumab
Glatiramer
Fingolimod
Teriflunomide
Dimetyl fumarate
Mitoxantrone

For detailed query about Uses, Side Effects, Contraindications, Interactions of opioid drugs, refer to individual drugs.

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