Cyproheptadine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Cyproheptadine is a first generation H1- receptor blocker with significant Anti-serotonin activity (5-HT2 –blocker), used in the treatment of the smooth muscle manifestations of carcinoid tumor, cold-induced urticaria, allergic reactions etc.
Dose : 4 mg (Oral)
Route : Oral
Plasma half-life : 8.6 hours
Duration of action : 4-6 hours
Bioavailability : ?
Chemical formula : C21H21N
IUPAC name : 4-(5H-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride
Trade name : Practin, Ciplactin, Periactin, Peritol
Therapeutic uses : Cyproheptadine has following usage :
- Cheifly used in the treatment of the smooth muscle manifestations of carcinoid tumor and in cold-induced urticaria.
- Useful in treating & preventing the allergic reactions.
- It have moderate sedative properties and maybe used in the treatment of insomnia (Somnifacient).
- Used as appetite stimulant due to its anti-serotonin activity.
Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors. Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are mentioned:
- Diminished alertness and concentration,
- Light headedness
- Motor incoordination,
- Fatigue and tendency to fall asleep
- Dryness of mouth
- Alteration of bowel movement
- Urinary hesitancy
- Blurring of vision
- Epigastric distress
- Acute overdose produces central excitation, tremors, hallucinations, muscular incordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.
Drug Interactions : Cyproheptadine may interact with following drugs :
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history, especially of respiratory problems, glaucoma, heart problems, high bp, liver disease, kidney disease, seizures, GIT problems, hyperthyroidism, urinary problems.
- This drug should not be used in newborn or premature infants.
- Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
- Hypersensitivity to Cyproheptadine and other drugs of similar chemical structure.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.