Cyproheptadine : Uses, Dosage, Side Effects, Interactions, & Contraindications

Cyproheptadine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names

Cyproheptadine is a first generation H1- receptor blocker with significant Anti-serotonin activity (5-HT2 –blocker), used in the treatment of the smooth muscle manifestations of carcinoid tumor, cold-induced urticaria, allergic reactions etc.
Dose : 4 mg (Oral)
Route : Oral
Plasma half-life : 8.6 hours
Duration of action : 4-6 hours
Bioavailability : ?
Chemical formula : C21H21N
IUPAC name : 4-(5H-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride
Trade name : Practin, Ciplactin, Periactin, Peritol
Therapeutic uses : Cyproheptadine has following usage :

  • Cheifly used in the treatment of the smooth muscle manifestations of carcinoid tumor and in cold-induced urticaria.
  • Useful in treating & preventing the allergic reactions.
  • It have moderate sedative properties and maybe used in the treatment of insomnia (Somnifacient).
  • Used as appetite stimulant due to its anti-serotonin activity.

Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors. Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are mentioned:

  1. Sedation
  2. Diminished alertness and concentration,
  3. Light headedness
  4. Motor incoordination,
  5. Fatigue and tendency to fall asleep
  6. Dryness of mouth
  7. Alteration of bowel movement
  8. Urinary hesitancy
  9. Blurring of vision
  10. Epigastric distress
  11. Headache
  12. Acute overdose produces central excitation, tremors, hallucinations, muscular incordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.

Drug Interactions : Cyproheptadine may interact with following drugs :


Before using this medication, tell your doctor or pharmacist

  • If you are allergic to it; or if you have any other allergies.
  • Your medical history, especially of respiratory problems, glaucoma, heart problems, high bp, liver disease, kidney disease,  seizures, GIT problems, hyperthyroidism, urinary problems.


  • This drug should not be used in newborn or premature infants.
  • Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  • Hypersensitivity to Cyproheptadine and other drugs of similar chemical structure.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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