Covifor : Uses, Dosage, Side Effects, Interactions, & Contraindications

Covifor : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications

Updated on 22nd June 2020. These materials are regularly updated based on new scientific findings & trials as the pandemic evolves.

Covifor is an antiviral medication developed by the Hetero Healthcare, Hyderabad, India. It is approved as treatment for Coronavirus Disease 2019 (COVID-19).

Generic name: Remdesivir
Dose : 100 mg
Route : Intravenous
Onset of action : N/A
Plasma half-life : N/A
Duration of action : N/A
Bioavailability : N/A
Plasma protein binding : N/A
Metabolism : N/A
Pregnancy risk category : N/A
Chemical formula : C27H35N6O8P
IUPAC name : (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
Therapeutic uses : Covifor is approved as treatment for COVID-19 patients in India only for restricted emergency use, a patient would need to sign a consent for before its administration.

The launching company, Hetero Healthcare, Hyderabad, India received marketing and manufacturing approval from the Indian drug regulator, Drug Controller General of India (DCGI) and launched the product in the Indian market.

  • Prescription:

200 mg on Day 1
100 mg for next 5 days

  • Price: Rs 5000-6000 per vial of 100 mg

Is remdesivir effective for COVID-19?

Data from clinical trials using the antiviral drug remdesivir to treat COVID-19 patients is encouraging, researchers report.

Mechanism of action 

Remdesivir (prodrug) that metabolizes into its active form GS-441524 (an adenosine nucleotide analog).

GS-441524 interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production.

Side effects

In the Ebola trial, researchers detected:

  • Increased liver enzyme levels that may or may not indicate liver damage.
    Researchers documented similar increases in liver enzymes in three U.S. COVID-19 patients.

Typical antiviral drug side effects include:

  • Nausea
  • Vomiting

Drug Interactions

  • There are no known significant interactions.


Before using this medication, tell your doctor or pharmacist

  • If you are allergic to it; or if you have any other allergies.
  • Your medical history.


  • Known hypersensitivity to RDV.
  • Severe renal impairment
  • High levels of liver enzymes
  • Pregnancy, & Lactation
  • Children below 12 years of age

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

Editor’s Note: Remdesivir is not FDA-approved. As a result, there is limited published information on this potential COVID-19 coronavirus treatment. The above article is sourced from various articles.

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