Cefpirome : Therapeutic uses, Dosage & Side Effects

Cefpirome : Therapeutic uses, Dosage & Side Effects

Cefpirome is the fourth generation cephalosporin antibiotic. Its zwitterion character permits better penetration through porin channels of gram-negative bacteria.
Dose : 1-2 g i.m./i.v. 12 hourly
Route : IM, IV
Onset of action : ?
Plasma Half-life : 1.8-2.2 hours
Duration of action : ?
Bioavailability : ?
Plasma protein binding : ?
Pregnancy risk category : C
Metabolism : ?
Chemical formula : C22H22N6O5S2
IUPAC name : 1-{[(6R,7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium
Trade name : Cefrom, Ceforth, Bacirom, Cefor, Keiten, Broact, Cefir
Antibacterial spectrum : Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. Cefpirome is resistant to many β-lactamases; inhibits type 1 β-lactamase producing Enterobacteriaceae and it is more potent against gram-positive and some gram-negative bacteria than the 3rd generation compounds.
Therapeutic uses : Cefpirome is indicated for the treatment of serious and resistant hospital-acquired infections including septicaemias, lower respiratory tract infections, etc.
Mechanism of action : Cephalosporins cause inhibition of bacterial cell wall synthesis. i.e. they have the same mechanism of action as penicillin. However, they bind to different proteins than those which bind penicillins.
Side effects : Cephalosporins are generally well tolerated, but are more toxic than penicillin. Cefpirome may provoke following side effects :

  • Vomiting, Diarrhea,
  • Colitis,
  • Dyspnea,
  • Headache,
  • Phlebitis, Rash
  • Vaginitis.

Drug Interactions : Cefpirome may interact with following drugs :

  • BCG vaccine live
  • Cholera vaccine
  • Typhoid vaccine live

Contraindications :

  • Contraindicated in patients having hypersensitivity to cephalosporins, penicillins.
  • Contraindicated during concomitant live bacterial vaccines

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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