Cefoperazone : Therapeutic uses, Dosage & Side Effects

Cefoperazone : Therapeutic uses, Dosage & Side Effects

Cefoperazone is the third generation cephalosporins. It is also sold as a co-formulation with sulbactam.
Dose : 1-3 g i.m./i.v. 8-12 hourly
Route : IM, IV
Onset of action : ?
Plasma Half-life : 2 hours
Duration of action : ?
Bioavailability : ?
Plasma protein binding : ?
Metabolism : ?
Pregnancy risk category : B
Chemical formula : C25H27N9O8S2
IUPAC name : (6R,7R)-7-[(2R)-2-{[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Trade name : Magnamycin, Cefomycin, Negaplus, Cefobid
Antibacterial spectrum : Cefoperazone is having stronger activity on Pseudomonas and weaker activity on other organisms. It is good for S. typhi and B. fragilis also, but more susceptible to β-lactamases.
Therapeutic uses : Cefoperazone is indicated for severe urinary, biliary, respiratory, skin-soft tissue infections, meningitis and septicaemias.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of drug and other antibacterial drugs, it should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.
Mechanism of action : Cephalosporins cause inhibition of bacterial cell wall synthesis. i.e. they have the same mechanism of action as penicillin. However, they bind to different proteins than those which bind penicillins.
Side effects : Cephalosporins are generally well tolerated, but are more toxic than penicillin. Cefoperazone may provoke following side effects :

  • Hypoprothrombinamia (but does not affect platelet function),
  • Hypersensitivity such as rash, Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis,
  • Nausea, vomiting and diarrhea,
  • Clostridium difficile associated diarrhea,
  • Transient elevations of BUN and creatinine,
  • Acute interstitial nephritis with renal failure.

Dosage reduction may be necessary in patients with liver dysfunction, concomitant alcohol use (disulfiram-like reaction), patients with a poor nutritional status, malabsorption states (eg, cystic fibrosis), and patients on prolonged hyperalimentation regimens are at high risk for cefoperazone-induced vitamin K deficiency.
Drug Interactions : Cefoperazone may interact with following drugs :

  • Alcohol : Disulfiram-like reaction,
  • Cholera vaccine, live
  • Heparin/Warfarin : an increased risk of bleeding

Contraindications :

  • Contraindicated in patients with known allergy to the cephalosporins.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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