Bupropion : Therapeutic uses, Dosage & Side Effects
Bupropion is a atypical antidepressant that inhibit dopamine and norepinephrine reuptake & used to alleviate the symptoms of depression.
Dose : 150-300 mg
Route : Oral
Plasma Half-life : 12-30 hours
Duration of action : N/A
Bioavailability : ?
Chemical formula : C13H18ClNO
IUPAC name : (RS)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one
Trade name : Smoquit, Wellbutrin, Zyban, Elontril, Aplenzin, Budeprion, Quomem, Prexaton, Voxra
Therapeutic uses :
Bupropion has following usage :
- Primarily indicated as anti-depressant drug for treating depression.
- Used for prevention of seasonal depressive disorder.
- Useful as a smoking cessation treatment for decreasing cravings and attenuating withdrawal symptoms of nicotine in patients trying to quit smoking.
- May improve symptoms of attention deficit hyperactivity disorder (ADHD).
- Has been used off-label for neuropathic pain and weight loss.
Note:- It has effects on sleep EEG that are opposite those of most antidepressant drugs.
Side effects :
Bupropion may produce following side effects:
- Dry mouth,
- Sweating,
- Nervousness,
- Tremor,
- Insomnia,
- Agitation,
- A dose dependent increased risk for seizures,
- Sexual dysfunction (very rare).
Contraindications :
- Use of bupropion should be avoided in patients at risk for seizures or those who have eating disorders such as bulimia.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.
