Buclizine : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Buclizine is a first generation H1- receptor blocker, useful in treating the allergic reactions.
Dose : 25-50 mg (Oral)
Route : Oral
Plasma half-life : ?
Duration of action : 4-6 hours
Bioavailability : ?
Chemical formula : C28H33ClN2
IUPAC name : (RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
Trade name : Longifene
Therapeutic uses : Buclizine has following usage :
- Useful in treating & preventing the allergic reactions.
- May be used for prevention of symptoms of Motion sickness. They are usually not effective if symptoms are already present and, thus, should be taken prior to expected travel.
- It has moderate sedation.
Side effects : First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors.
Some side effects may be undesirable, and others may be of therapeutic value. Following side effects are observed:
- Sedation
- Diminished alertness and concentration,
- Light headedness
- Motor incoordination,
- Fatigue and tendency to fall asleep
- Dryness of mouth
- Alteration of bowel movement
- Urinary hesitancy
- Blurring of vision
- Epigastric distress
- Headache
- Acute overdose produces central excitation, tremors, hallucinations, muscular incoordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.
Drug Interactions : Buclizine may interact with following drugs :
Precautions
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history.
Contraindications
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.