Biperiden : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names
Biperiden is a synthetic anti-muscarinic cholinergic Antagonist, used as adjunct to treat Parkinson’s disease, Parkinsonian syndromes, including antipsychoticinduced extrapyramidal symptoms.
Dose : 2-10 mg
Route : Oral, Intra-muscular(I.M.), Intra-venous(I.V.)
Plasma half-life : 18-24 hours
Duration of action : 18-24 hours
Bioavailability : 33 ± 5% (oral)
Chemical formula : C21H29NO
IUPAC name : (1RS,2SR,4RS)-1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin- 1-yl)propan-1-ol
Trade name : Dyskinon, Akineton
Therapeutic uses : Biperiden is used as adjunct to treat Parkinson’s disease, Parkinsonian syndromes, including antipsychoticinduced extrapyramidal symptoms.
Side effects : Commonly observed side effects are as follows :
- Xerostomia (dryness of the mouth),
- Mood alterations,
- Visual problems,
- Interfere with gastrointestinal peristalsis and are contraindicated in patients with glaucoma, prostatic hyperplasia, or pyloric stenosis,
- Urinary retention,
- Constipation,
- Impairment of memory and organic confusional states (more common in the elderly.)
Drug Interactions : Biperiden may interact with following drugs :
Precautions
Before using this medication, tell your doctor or pharmacist
- If you are allergic to it; or if you have any other allergies.
- Your medical history.
Contraindications
- Narrow angle glaucoma.
- Bowel obstruction or megacolon.
- Known hypersensitivity to biperiden or any ingredient in the formulation.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.