Aripiprazole : Therapeutic uses, Dosage & Side Effects

Aripiprazole : Therapeutic uses, Dosage & Side Effects

Aripiprazole is a second-generation atypical antipsychotic drug, used in treating schizophrenia. It may also be used for other conditions as determined by your doctor.
Dose : 5-30 mg
Route : Oral, IM
Plasma Half-life : 3 days
Duration of action : Long
Bioavailability : 87%
Chemical formula : C23H27Cl2N3O2
IUPAC name : 7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
Trade name : Aripra, Arilan, Bilief, Arive, Abilify
Therapeutic uses :  Aripiprazole has following usage :

  • Primarily indicated as anti-psychotic drug for treating psychoses particularly Schizophrenia (generally first-line therapy). It may be effective in many patients who are resistant to the first generation agents, especially in treating the negative symptoms of schizophrenia.
  • Indicated for the treatment of bipolar disorder, mania.
  • Used as adjunctive agents with antidepressants for treatment of refractory depression.
  • Approved for the management of disruptive behavior and irritability secondary to autism
  • Can be used as tranquilizers to manage agitated and disruptive behavior secondary to other disorders.
  • May relieve anxiety.
  • May be used for Organic brain syndromes on a short-term basis.
  • Rare indications includes Alcoholic hallucinosis, Huntington’s disease and Gilles de Ia Tourette’s syndrome.

Side effects :  Adverse effects of the Aripiprazole can occur in practically all patients and are significant in about 80% ; Aripiprazole may produce following side effects:

  • CNS ailments like light-headedness,
  • Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary incontinence
  • Dyspepsia, Nausea
  • Rarely Hyperprolactinemia – amenorrhoea, infertility, galactorrhoea and gynaecomastia
  • Rarely Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute muscular dystonias, Akathisia, Malignant neuroleptic syndrome, Tardive dyskinesia

Contraindications :

  • It should be used cautiously in patients with seizure disorders (since it may lower the seizure threshold)or those with an increased risk for seizures, such as withdrawal from alcohol.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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