Apraclonidine : Therapeutic uses, Dosage & Side Effects
Apraclonidine is a α adrenergic agonist (relatively selective α2 adrenergic agonist), used to reduce Intra-ocular pressure.
Dose : 0.5-1 % opthalmic solution
Route : Topical
Plasma half-life : 8 hours
Duration of action : N/A
Bioavailability : ?
Chemical formula : C9H10Cl2N4
IUPAC name : 2,6-Dichloro-N– (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Trade name : Iopidine
Therapeutic uses :
Apraclonidine has following usage :
- Used topically to reduce intraocular pressure. It can reduce elevated as well as normal intraocular pressure whether accompanied by glaucoma or not.
- Used to control or prevent elevations in intraocular pressure that occur in patients after laser trabeculoplasty or iridotomy.
Note :- Apraclonidine is more useful than clonidine for ophthalmic therapy because apra-clonidine causes reduction in intraocular pressure occurs with minimal or no effects on systemic cardiovascular parameters.
Directions for use : 1 to 2 drops should be instilled in the affected eye(s) 3 times per day or as directed by your doctor.
Side effects : Adverse effects of Apraclonidine are as follows:
- Lid dermatitis,
- Follicular conjunctivitis,
- Eyelid retraction,
- Dryness of mouth and nose,
- Red eye and ocular irritation,
- Allergic reactions,
- It is contraindicated in patients with hypersensitivity to Apra-clonidine or any other component of this medication, as well as systemic clonidine.
- It is also contraindicated in patients receiving monoamine oxidase inhibitors (MAO inhibitors).
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.