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Apraclonidine : Therapeutic uses, Dosage & Side Effects

Apraclonidine : Therapeutic uses, Dosage & Side Effects

Apraclonidine is a α adrenergic agonist (relatively selective α2 adrenergic agonist), used to reduce Intra-ocular pressure.
Dose : 0.5-1 % opthalmic solution
Route : Topical
Plasma half-life : 8 hours
Duration of action : N/A
Bioavailability : ?
Chemical formula : C9H10Cl2N4
IUPAC name : 2,6-Dichloro-N– (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Trade name : Iopidine
Therapeutic uses :
Apraclonidine has following usage :

  • Used topically to reduce intraocular pressure. It can reduce elevated as well as normal intraocular pressure whether accompanied by glaucoma or not.
  • Used to control or prevent elevations in intraocular pressure that occur in patients after laser trabeculoplasty or iridotomy.

Note :- Apraclonidine is more useful than clonidine for ophthalmic therapy because apra-clonidine causes reduction in intraocular pressure occurs with minimal or no effects on systemic cardiovascular parameters.
Directions for use : 1 to 2 drops should be instilled in the affected eye(s) 3 times per day or as directed by your doctor.

Side effects : Adverse effects of Apraclonidine are as follows:

  • Itching,
  • Lid dermatitis,
  • Follicular conjunctivitis,
  • Mydriasis,
  • Eyelid retraction,
  • Dryness of mouth and nose,
  • Red eye and ocular irritation,
  • Allergic reactions,
  • Malaise,
  • Headache.

Contraindications :

  • It is contraindicated in patients with hypersensitivity to Apra-clonidine or any other component of this medication, as well as systemic clonidine.
  • It is also contraindicated in patients receiving monoamine oxidase inhibitors (MAO inhibitors).

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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