Antigout Drugs (Drugs for Gout)

Antigout Drugs (Drugs for Gout)

Gout is a metabolic disorder characterized by hyperuricaemia (normal plasma urate 1-4 mg/ dl).

1. Drugs for acute gout

Acute gout manifests as sudden onset of severe inflammation in a small joint (commonest is metatarso-phalangeal joint of great toe) due to precipitation of urate crystals in the joint space.


  • One of the strong anti-inflammatory drugs is given in relatively high and quickly repeated doses.
  • They are quite effective in terminating the attack, but may take 12-24 hours, i.e. response is somewhat slower than with colchicine, but they are generally better tolerated; majority of patients prefer them over colchicine.
  • Their strong anti-inflammatory (not uricosuric) action is responsible for the benefit.


  • Indomethacin
  • Naproxen
  • Piroxicam
  • Diclofenac
  • Etoricoxib


  • Colchicine is neither analgesic nor antiinflammatory, but it specifically suppresses gouty inflammation.
  • It does not inhibit the synthesis or promote the excretion of uric acid. Thus, it has no effect on blood uric acid levels.


  • Intra-articular injection of a soluble steroid suppresses symptoms of acute gout.
  • Crystalline preparation should not be used.
  • It is indicated infractory cases and those not tolerating NSAIDs/Colchicine.

2. Drugs for chronic gout or hyperuraecemia

When pain and stiffness persist in a joint between attacks, gout has become chronic.



  • Probenecid
  • Sulfinpyrazone
  • Pegloticase

Synthesis inhibitor


  • Allopurinol
  • Febuxostat
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