Tyrothricin : Therapeutic uses, Dosage & Side Effects
Tyrothricin is a polypeptide antibiotic. It is a mixture of gramicidin and tyrocidin. It is not absorbed orally.
Dose : ?
Route : Topical
Onset of action : ?
Plasma Half-life : ?
Duration of action : ?
Bioavailability : ?
Plasma protein binding : ?
Metabolism : ?
Pregnancy risk category : ?
Chemical formula : C65H85N11O13
IUPAC name : ?
Trade name : Tyroderm, Prothricin, Tyotocin, Limexx, Tyrosur
Antibacterial spectrum : Tyrothricin is active against gram-positive and a few gram-negative bacteria.
Therapeutic uses : Tyrothricin is used for inflammation of the throat, gastric mucosa, and angina tonsillaris provided that the mucous membrane must be intact. It is used only topically; does not cause sensitization.
Mechanism of action : Tyrothricinacts on cell membrane causing leakage and uncouples oxidative phosphorylation in the bacteria.
Side effects : Tyrothricinis too toxic for systemic use; causes haemolysis. It may also cause following adverse effect :
- Hypersensitivity reactions
- Temporary loss of balance
- Nephrotoxic effects
- Contraindicated in persons having allergic reactions with formulation.
For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.