Hydroxyzine : Therapeutic uses, Dosage & Side Effects

Hydroxyzine : Therapeutic uses, Dosage & Side Effects

Hydroxyzine is a first generation H1- receptor blocker (Anti-histamine), used as a sedative to treat anxiety, & tension. It may also be used to control nausea & vomiting, and allergic skin reactions such as hives or contact dermatitis.
Dose : 25-50 mg (Oral)
Route : Oral, Intra-muscular (I.M.)
Plasma half-life : 20–24 hours
Duration of action : 4-24 hours
Bioavailability : High
Chemical formula : C21H27ClN2O2
IUPAC name : (±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl}ethoxy)ethanol
Trade name : Atarax, Vistaril, Alamon, Aterax, Durrax, Tran-Q, Orgatrax, Quiess, Tranquizine, Equipose, Masmoran, Paxistil
Therapeutic uses :
Hydroxyzine has following usage :
  • It have strong sedative properties and are used in the treatment of insomnia (Somnifacient/Sleep aid) & Anxiety.
  • Useful in treating & preventing the allergic reactions.
  • Can be used for prevention of symptoms of Motion sickness (e.g. nausea, vertigo, vomiting etc). They are usually not effective if symptoms are already present and, thus, should be taken prior to expected travel.
  • It is also used together with other medications given for anesthesia.

Side effects :
First-generation H1-receptor blockers have a low specificity, interacting not only with histamine receptors but also with muscarinic cholinergic receptors, α-adrenergic receptors, and serotonin receptors. Some side effects may be undesirable, and others may be of therapeutic value, Following side effects are encountered:

  • Sedation
  • Diminished alertness and concentration,
  • Light headedness
  • Motor incoordination,
  • Fatigue and tendency to fall asleep
  • Dryness of mouth
  • Alteration of bowel movement
  • Urinary hesitancy
  • Blurring of vision
  • Epigastric distress
  • Headache
  • Acute overdose produces central excitation, tremors, hallucinations, muscular incordination, convulsions, flushing, hypotension, fever and some other features of belladonna poisoning. Death is due to respiratory and cardiovascular failure.

Contraindications :

  • It is contraindicated for patients who have shown a previous hypersensitivity to any component of this medication.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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