Bacitracin : Uses, Dosage, Side Effects, Interactions, & Contraindications

Bacitracin : Therapeutic uses, Clinical uses, Indications, Dosage, Side Effects, Warnings, Interactions, Precautions, Contraindications & Brand names

Bacitracin is a polypeptide antibiotic obtained from a strain of Bacillus subtilis. It is not used parenterally because of high toxicity, especially to the kidney. It is used to prevent minor skin infections caused by small cuts, scrapes, or burns.
Dose : ?
Route : Topical
Onset of action : ?
Plasma Half-life : ?
Duration of action : ?
Bioavailability : ?
Plasma protein binding : ?
Metabolism : ?
Pregnancy risk category : C
Chemical formula : C66H103N17O16S
IUPAC name : (4R)-4-[(2S)-2-({2-[(1S)-1-amino-2-methylbutyl]- 4,5-dihydro-1,3-thiazol-5-yl}formamido)-4-methylpentanamido]-4-{[(1S)- 1-{[(3S,6R,9S,12R,15S,18R,21S)- 18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)- 6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20- heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}- 2-methylbutyl]carbamoyl}butanoic acid
Trade name : Neosporin, Nebasulf, Baciim
Antibacterial spectrum : Bacitracin is active mainly against gram-positive organisms (both cocci and bacilli). Neisseria, H. influenzae and few other bacteria are also affected. It is a bactericidal antibiotic.
Therapeutic uses : Bacitracin use is restricted to topical application for infected wounds, ulcers, eye infections-generally in combination with neomycin, polymyxin, etc. It does not penetrate intact skin, therefore, of little value in furunculosis, boils, carbuncles, etc.
Mechanism of action : Bacitracin acts by inhibiting cell wall synthesis at a step earlier than that inhibited by penicillin. Subsequently, it increases the efflux of ions by binding to cell membrane.

Side effects : Though many people have no or minor side effects, bacitracin may cause following side effects :

  • Allergic reactions such as rash, hives, itching
  • Difficulty in breathing
  • Burning
  • Redness, swelling
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue.

Drug Interactions


  • Contraindicated in persons having hypersensitivity to drug.

For detailed query or in case of uncertainty, Always consult your doctor or pharmacist.

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